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Effect of metabolic control on parathyroid hormone secretion in diabetic patients
Paula, F. J. A; Lanna, C. M. M; Shuhama, T; Foss, M. C.
  • Paula, F. J. A; Universidade de Säo Paulo. Faculdade de Medicina de Ribeiräo Preto. Departamento de Clínica Médica. Ribeiräo Preto. BR
  • Lanna, C. M. M; Universidade de Säo Paulo. Faculdade de Medicina de Ribeiräo Preto. Departamento de Clínica Médica. Ribeiräo Preto. BR
  • Shuhama, T; Universidade de Säo Paulo. Faculdade de Medicina de Ribeiräo Preto. Departamento de Clínica Médica. Ribeiräo Preto. BR
  • Foss, M. C; Universidade de Säo Paulo. Faculdade de Medicina de Ribeiräo Preto. Departamento de Clínica Médica. Ribeiräo Preto. BR
Braz. j. med. biol. res ; 34(9): 1139-1145, Sept. 2001. tab, graf
Article in English | LILACS | ID: lil-290400
ABSTRACT
The metabolic derangement caused by diabetes mellitus may potentially affect bone mineral metabolism. In the present study we evaluated the effect of diabetes metabolic control on parathyroid hormone (PTH) secretion during stimulation with EDTA infusion. The study was conducted on 24 individuals, 8 of them normal subjects (group N glycated hemoglobin - HbA1C = 4.2 + or - 0.2 percent; range = 3.5-5.0 percent), 8 patients with good and regular metabolic control (group G-R HbA1C = 7.3 + or - 0.4 percent; range = 6.0-8.5 percent), and 8 patients with poor metabolic control (group P HbA1C = 12.5 + or - 1.0 percent; range 10.0-18.8 percent). Blood samples were collected at 10-min intervals throughout the study (a basal period of 30 min and a 2-h period of EDTA infusion, 30 mg/kg body weight) and used for the determination of ionized calcium, magnesium, glucose and intact PTH. Basal ionized calcium levels were slightly lower in group P (1.19 + or - 0.01 mmol/l) than in group N (1.21 + or - 0.01 mmol/l) and group G-R (1.22 + or - 0.01 mmol/l). After EDTA infusion, the three groups presented a significant fall in calcium, but with no significant difference among them at any time. Basal magnesium levels and levels determined during EDTA infusion were significantly lower (P<0.01) in group P than in group N. The induction of hypocalcemia caused an elevation in PTH which was similar in groups N and G-R but significantly higher than in group P throughout the infusion period (+110 min, N = 11.9 + or - 2.1 vs G-R = 13.7 + or - 1.6 vs P = 7.5 + or - 0.7 pmol/l; P<0.05 for P vs N and G-R). The present results show that PTH secretion is impaired in patients with poorly controlled diabetes
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Parathyroid Hormone / Diabetes Mellitus Type of study: Etiology study Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2001 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Säo Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Parathyroid Hormone / Diabetes Mellitus Type of study: Etiology study Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2001 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Säo Paulo/BR