Alteraçoes no teste ultra-rápido da urease e no exame anatomopatológico para Helicobacter pylori induzidas por drogas anti-secretoras / Changes in ultrarapid urease test and histopathological examination for Helicobacter pylori by antisecretory drugs
Arq. gastroenterol
;
38(1): 3-7, Jan.-Mar. 2001. tab
Article
in Portuguese
| LILACS
| ID: lil-290411
ABSTRACT
One of the major problems when evaluating dyspeptic patients at public hospitals is the large interval between the consultation and the endoscopy, leading to the prescription of antisecretory drugs, what can be responsible for false results on examinations. AIM:
To evaluate changes in ultrarapid urease test and histopathological examination for Helicobacter pylori by antisecretory drugs.METHODS:
In a prospective double-blind study, 50 patients with dyspeptic complaints and endoscopic diagnosis of peptic ulcer, erosive gastritis, esophagitis or duodenitis, with a positive urease test, were randomized to a 7-day course of treatment with either omeprazole 20 mg or ranitidine 300 mg a day. Before and after treatment, two biopsy specimens each were obtained from the antrum and corpus and an ultrarapid urease test and a histopathological examination for Helicobacter pylori were performed.RESULTS:
There were no significant changes in the results of ultrarapid urease test and histopathological examination for Helicobacter pylori after treatment with ranitidine. With omeprazole, we observed a decrease in positive results in ultrarapid urease test and histopathological examination for Helicobacter pylori in the antrum, but not in the corpus.CONCLUSION:
Omeprazole, used for 7 days, can lead to negative results in ultrarapid urease test and histopathological examination for Helicobacter pylori in the antrum, and should not be employed in patients before the endoscopy is performed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Urease
/
Helicobacter pylori
/
Helicobacter Infections
/
Gastrointestinal Diseases
/
Histamine H2 Antagonists
/
Anti-Ulcer Agents
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Portuguese
Journal:
Arq. gastroenterol
Journal subject:
Gastroenterology
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Juiz de Fora/BR
/
Universidade Federal de Säo Paulo/BR
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