Alelos HLA DQ alfa maternos, pérdida recurrente del embarazo y síndrome de anticuerpos antifosfolípidos

RESUMO

Autoantibodies to phospholopids antigens APL, are associated with a history of RSA in women without autoinmunedisease. APL interfere with the production of prostaciclin allowing the increase of thrombotic events. Phospholipids are compounds of placental mebrane structure and also they have been considered as an adhesion molecules participating in the formation of syncytotrophoblast. Trophoblastic antigens can induce the production of antiphospholipids antibodies. This antiboidies can delay the trophoblast development by the action in the adhesion molecules. We have studied 270 women with RSA and 31 women as a control group which had normal pregnancies. The testing incluided antiphospholopid antibodies and genetic evaluation of class II DQ antigens of the couple. We have showed APL titles no gretaer than 1/25 in normal pregnant women. In RSA the incidence increases in a fifteen percent with each subsequent pregnancy loss. We observed an strong correlation between maternal HLA DQ alfa 4.1 (0501) and increases in APL titles in patients who loss their pregnancy again