ECLAMC: estudio de 30 años de vigilancia epidemiológica de defectos de tubo neural en Chile y en Latinoamérica / ECLAMC: results of 30 years of epidemiological surveillance of neural tube defects in Chile and Latin America
Rev. méd. Chile
;
129(5): 531-9, mayo 2001. tab, graf
Article
in Spanish
| LILACS
| ID: lil-295255
ABSTRACT
Background:
There is an urgent need to assess the impact, on the incidence of neural tube defects, of the recently implanted flour fortification with folic acid in Chile. The Collaborative Study of Congenital Malformations in Latin America (ECLAMC) has carried out an uninterrupted register of congenital malformations in the last thirty yearsAim:
To assess the epidemiology of neural tube defects in Chile and determine the most adequate base period to evaluate the effects of Folic acid fortification. Material andmethods:
analysis of ECLAMC database that has registered all births over 500 g from 1967.Results:
From 1967 to 1999, there were 434.624 births in 18 hospitals in Chile and 3.586.569 births in 155 hospitals in the rest of Latin America. The rate of neural tube defects in Chile was 17.03 per 10.000, significantly higher than the rest of ECLAMC (14.88 per 10.000). The prevalence of neural tube defects has a statistically significant secular tendency to increase in the study period and is higher among stillbirths, newborns with a birth weight of less than 1500 g, women and offspring of mothers aged less than 19 years old.Conclusions:
The period 1982-1999 is considered the best period for reference comparisons of the effects folic acid supplementation
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Epidemiological Monitoring
/
Neural Tube Defects
Type of study:
Etiology study
/
Risk factors
/
Screening study
Limits:
Humans
/
Infant, Newborn
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2001
Type:
Article
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