Hereditary spastic paraplegia associated with thin corpus callosum
Arq. neuropsiquiatr
;
59(3B): 790-792, Sept. 2001. ilus
Article
in English
| LILACS
| ID: lil-295850
ABSTRACT
Autosomal recessive hereditary spastic paraplegia (AR-HSP) associated with thin corpus callosum was recently described in Japan, and most families were linked to chromosome 15q13-15. We report two patients from two different Brazilian families with progressive gait disturbance starting at the second decade of life, spastic paraparesis, and mental deterioration. One patient presented cerebellar ataxia. Magnetic resonance imaging (MRI) of the head of both patients showed a thin corpus callosum. AR-HSP with a thin corpus callosum is a rare disorder, mainly described in Japanese patients. We found only 4 Caucasian families with AR-HSP with thin corpus callosum described in the literature. Further studies including additional Caucasian families of AR-HSP with thin corpus callosum are required to delineate the genetic profile of this syndrome in occidental countries
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Spastic Paraplegia, Hereditary
/
Corpus Callosum
Type of study:
Diagnostic study
/
Risk factors
Limits:
Adolescent
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Paraná/BR
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