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The impact of repeated treatment with praziquantel of schistosomiasis in children under six years of age living in an endemic area for Schistosoma haematobium infection
Mduluza, T; Ndhlovu, P. D; Madziwa, T. M; Midzi, N; Zinyama, R; Turner, C. M. R; Chandiwana, S. K; Nyazema, N; Hagan, P.
  • Mduluza, T; University of Zimbabwe. Department of Biochemistry. Harare. ZW
  • Ndhlovu, P. D; University of Zimbabwe. Department of Biochemistry. Harare. ZW
  • Madziwa, T. M; University of Zimbabwe. Department of Pharmacy. Harare. ZW
  • Midzi, N; Blair Research Institute. Harare. ZW
  • Zinyama, R; Blair Research Institute. Harare. ZW
  • Turner, C. M. R; University of Glasgow. Division of Infection and Immunity. Glasgow. GB
  • Chandiwana, S. K; University of Zimbabwe. Department of Biochemistry. Harare. ZW
  • Nyazema, N; University of Zimbabwe. Department of Pharmacy. Harare. ZW
  • Hagan, P; University of Glasgow. Division of Infection and Immunity. Glasgow. GB
Mem. Inst. Oswaldo Cruz ; 96(suppl): 157-164, Sept. 2001. tab
Article in English | LILACS | ID: lil-295894
Responsible library: BR1.1
ABSTRACT
Praziquantel was given every eight weeks for two years to children aged under six years of age, living in a Schistosoma haematobium endemic area. Infection with S. haematobium and haematuria were examined in urine and antibody profiles (IgA, IgE, IgM, IgG1, IgG2, IgG3, and IgG4) against S. haematobium adult worm and egg antigens were determined from sera collected before each treatment. Chemotherapy reduced infection prevalence and mean intensity from 51.8 percent and 110 eggs per 10 ml urine, respectively, before starting re-treatment programme to very low levels thereafter. Praziquantel is not accumulated after periodic administration in children. Immunoglobulin levels change during the course of treatment with a shift towards 'protective' mechanisms. The significant changes noted in some individuals were the drop in 'blocking' IgG2 and IgG4 whereas the 'protecting' IgA and IgG1 levels increased. The antibody profiles in the rest of the children remained generally unchanged throughout the study and no haematuria was observed after the second treatment. The removal of worms before production of large number of eggs, prevented the children from developing morbidity
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Praziquantel / Schistosomiasis haematobia / Anthelmintics Limits: Animals / Humans Country/Region as subject: Africa Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2001 Type: Article Affiliation country: United kingdom / Zimbabwe Institution/Affiliation country: Blair Research Institute/ZW / University of Glasgow/GB / University of Zimbabwe/ZW
Full text: Available Index: LILACS (Americas) Main subject: Praziquantel / Schistosomiasis haematobia / Anthelmintics Limits: Animals / Humans Country/Region as subject: Africa Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2001 Type: Article Affiliation country: United kingdom / Zimbabwe Institution/Affiliation country: Blair Research Institute/ZW / University of Glasgow/GB / University of Zimbabwe/ZW