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T cell clones from Schistosoma haematobium infected and exposed individuals lacking distinct cytokine profiles for Th1/Th2 polarisation
Mduluza, T; Ndhlovu, P. D; Midzi, N; Mary, C; Paris, C. P; Turner, C. M. R; Chandiwana, S. K; Woolhouse, M. E. J; Dessein, A. J; Hagan, P.
  • Mduluza, T; University of Zimbabwe. Biochemistry Department. Harare. ZW
  • Ndhlovu, P. D; University of Zimbabwe. Biochemistry Department. Harare. ZW
  • Midzi, N; University of Zimbabwe. Biochemistry Department. Harare. ZW
  • Mary, C; Faculte de Medicine. INSERM U399. Marseille. FR
  • Paris, C. P; Faculte de Medicine. INSERM U399. Marseille. FR
  • Turner, C. M. R; University of Glasgow. IBLS. Division of Infection and Immunity. Glasgow. GB
  • Chandiwana, S. K; University of Zimbabwe. Biochemistry Department. Harare. ZW
  • Woolhouse, M. E. J; University of Oxford. Department of Zoology. Oxford. GB
  • Dessein, A. J; Faculte de Medicine. INSERM U399. Marseille. FR
  • Hagan, P; University of Glasgow. IBLS. Division of Infection and Immunity. Glasgow. GB
Mem. Inst. Oswaldo Cruz ; 96(suppl): 89-101, Sept. 2001. ilus, graf, tab
Article in English | LILACS | ID: lil-295895
Responsible library: BR1.1
RESUMO
T cell clones were derived from peripheral blood mononuclear cells of Schistosoma haematobium infected and uninfected individuals living in an endemic area. The clones were stimulated with S. haematobium worm and egg antigens and purified protein derivative. Attempts were made to classify the T cell clones according to production of the cytokines IL-4, IL-5 and IFN-gamma. All the T cell clones derived were observed to produce cytokines used as markers for the classification of Th1/Th2 subsets. However, the 'signature' cytokines marking each subset were produced at different levels. The classification depended on the dominating cytokine type, which was having either Th0/1 or Th0/2 subsets. The results indicated that no distinct cytokine profiles for polarisation of Th1/Th2 subsets were detected in these S. haematobium infected humans. The balance in the profiles of cytokines marking each subset were related to infection and re-infection status after treatment with praziquantel. In the present study, as judged by the changes in infection status with time, the T cell responses appeared to be less stable and more dynamic, suggesting that small quantitative changes in the balance of the cytokines response could result in either susceptibility or resistant to S. haematobium infection
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Schistosoma haematobium / Schistosomiasis haematobia / Cytokines / T-Lymphocytes, Helper-Inducer Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2001 Type: Article / Project document Affiliation country: France / United kingdom / Zimbabwe Institution/Affiliation country: Faculte de Medicine/FR / University of Glasgow/GB / University of Oxford/GB / University of Zimbabwe/ZW

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Full text: Available Index: LILACS (Americas) Main subject: Schistosoma haematobium / Schistosomiasis haematobia / Cytokines / T-Lymphocytes, Helper-Inducer Limits: Animals / Humans Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2001 Type: Article / Project document Affiliation country: France / United kingdom / Zimbabwe Institution/Affiliation country: Faculte de Medicine/FR / University of Glasgow/GB / University of Oxford/GB / University of Zimbabwe/ZW