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Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages
Bastos, A. C. S. C; Santos, L. B; Tamashiro, W. M. S. C; Yamada, A. T; Oliveira, U. M; Yano, T.
  • Bastos, A. C. S. C; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Microbiologia e Imunologia. Campinas. BR
  • Santos, L. B; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Microbiologia e Imunologia. Campinas. BR
  • Tamashiro, W. M. S. C; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Microbiologia e Imunologia. Campinas. BR
  • Yamada, A. T; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Histologia e Embriologia. Campinas. BR
  • Oliveira, U. M; Universidade Estadual de Campinas. Faculdade de Medicina. Departamento de Patologia Clínica. Campinas. BR
  • Yano, T; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Microbiologia e Imunologia. Campinas. BR
Braz. j. med. biol. res ; 34(7): 913-917, July 2001. ilus, tab
Article in English | LILACS | ID: lil-298665
ABSTRACT
Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 æg/ml and 50 æg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 æg/ml and 1250 æg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages
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Full text: Available Index: LILACS (Americas) Main subject: Phagocytosis / Adjuvants, Immunologic / Macrophages, Peritoneal / Fimbriae, Bacterial / Escherichia coli Limits: Animals / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2001 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Phagocytosis / Adjuvants, Immunologic / Macrophages, Peritoneal / Fimbriae, Bacterial / Escherichia coli Limits: Animals / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2001 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR