Hepatitis B vaccine in infants: a randomized controlled trial comparing gluteal versus anterolateral thigh muscle administration
Rev. Inst. Med. Trop. Säo Paulo
;
43(3): 139-143, May-June 2001. tab
Article
in English
| LILACS
| ID: lil-298903
RESUMO
A significantly diminished antibody response to hepatitis B vaccine has been demonstrated in adults when the buttock is used as the injection site. However, in Brazil, the buttock continues to be recommended as site of injection for intramuscular administration of vaccines in infants. In this age group, there are no controlled studies evaluating the immunogenicity of the hepatitis B vaccine when administered at this site. In the present study, 258 infants were randomized to receive the hepatitis B vaccine either in the buttock (n = 123) or in the anterolateral thigh muscle (n = 135). The immunization schedule consisted of three doses of hepatitis B vaccine (Engerix BFACE="Symbol">â, 10 mug) at 2, 4 and 9 months of age. There were no significant differences in the proportion of seroconversion (99.3 percent x 99.2 percent), or in the geometric mean titer of ELISA anti-HBs (1,862.1 x 1,229.0 mIU/mL) between the two groups. This study demonstrates that a satisfactory serological response can be obtained when the hepatitis B vaccine is administered intramuscularly into the buttock
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immunization Schedule
/
Hepatitis B Vaccines
/
Injections, Intramuscular
Type of study:
Controlled clinical trial
Limits:
Humans
/
Infant
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fleury Laboratories/BR
/
Government of Säo Paulo State/BR
/
Universidade Federal de Säo Paulo/BR
/
Universidade de Säo Paulo/BR
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