Carga viral en liquido cefalorraquideo de pacientes hemofílicos HIV-1 positivos bajo tratamiento con HAART / Cerebrospinal fluid viral load in HIV-1 positive hemophilic patients treated with HAART
Medicina (B.Aires)
;
61(6): 821-4, 2001. tab
Article
in Spanish
| LILACS
| ID: lil-300784
RESUMO
As HIV seropositive patients with undetectable CSF viral load have a lower likelihood of developing neurologic disease, the determination of CSF viral load levels may be useful to evaluate the efficacy of HAART. We compared plasma viral load levels with HIV-1 RNA CSF levels in 18 hemophilic patients without neurocognitive involvement under HAART. We detected a significant correlation between plasma viral load levels and CSF viral load levels. Fourteen patients with undetectable plasma viral load had undetectable RNA HIV-1 CSF levels as well. Four patients with detectable plasma viral load had detectable HIV-RNA in CSF, but the latter were significantly lower. Viral load is usually lower in non-blood fluids and HAART decreases the viral load in CSF as well as in blood.
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Index:
LILACS (Americas)
Main subject:
RNA, Viral
/
HIV Infections
/
HIV-1
/
Viral Load
/
Antiretroviral Therapy, Highly Active
/
Hemophilia A
Limits:
Humans
Language:
Spanish
Journal:
Medicina (B.Aires)
Journal subject:
Medicine
Year:
2001
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Fundación Argentina de la Hemofilia/AR
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