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Effects of acute and chronic administration of benzydamine on the stimulatory effects of ethanol in mice
Buscariolo, Inês Aparecida; Planeta, Cleópatra da Silva; Delucia, Roberto.
  • Buscariolo, Inês Aparecida; Universidade de Säo Paulo. Faculdade de Odontologia. Departamento de Estomatologia. BR
  • Planeta, Cleópatra da Silva; Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas. Departamento de Princípios Ativos e Naturais e Toxicologia. Araraquara. BR
  • Delucia, Roberto; Universidade de Säo Paulo. Departamento de Farmacologia. BR
Rev. ciênc. farm ; 21(1): 117-124, 2000. graf
Article in English | LILACS | ID: lil-301778
ABSTRACT
Acute and chronic effects of benzydamine (BEZ) and its interactions with ethanol (EtOH) were examined on open field locomotion. Male Swiss mice were injected intraperitoneally (i.p.) with 15, 30 or 60 mg kg of BEZ alone or in combination with EtOH (2.0 mg/k, i.p.). Pretreatment with BEZ (60 mg/kg) produced a significant decrease in EtOH-induced behavioral stimulation. Chronic administration of BEZ (15mg/kg/day for 21 days) intensified locomotor response induced by EtOH, suggesting the development of behavioral sensitization. The results show that BEZ can interact with EtOH suggesting that alcohol drinkers should be educated about risks of BEZ toxicity.
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Index: LILACS (Americas) Main subject: Benzydamine Limits: Animals Language: English Journal: Rev. ciênc. farm Journal subject: Pharmacology Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR / Universidade de Säo Paulo/BR

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Index: LILACS (Americas) Main subject: Benzydamine Limits: Animals Language: English Journal: Rev. ciênc. farm Journal subject: Pharmacology Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR / Universidade de Säo Paulo/BR