Efecto de la terapia hormonal de reemplazo que incluye un progestágeno sobre la sensibilidad a la insulina y el perfil de lípidos en la mujer en etapa de posmenopausia / Effects of hormone replacement therapy including a progestin on insulin sensitivity and lipid profile in postmenopausal women
Rev. méd. Chile
;
129(9): 989-994, sept. 2001. tab, graf
Article
in Spanish
| LILACS
| ID: lil-302028
ABSTRACT
Background: The cardiovascular protective properties of hormone replacement therapy can be hampered when a progestin is used. Aim: To assess the effects of hormone replacement therapy with progestins on insulin sensitivity and lipid profile. Patients and methods: Twelve healthy postmenopausal women aged 45 to 55 years old were studied. Blood lipids and insulin sensitivity, determined using the insulin tolerance test, were measured at baseline and after three months of hormone replacement therapy using conjugated estrogens, 0.625 mg/day and medroxyprogesterone acetate, 5 mg/day. Results: The glucose disappearance constant was higher after the treatment period than at baseline (5.3ñ0.8 and 4.7ñ0.8 percent/min respectively, p = 0.005). Serum LDL cholesterol was also lower at the end of treatment period (124.5 ñ 30.2 and 140ñ25.4 mg/dl respectively, p = 0.019). Conclusions: In this group of postmenopausal women, a period of three months of hormone replacement therapy with a progestin improved insulin sensitivity and lowered LDL cholesterol levels
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Progestins
/
Insulin Resistance
/
Estrogen Replacement Therapy
/
Lipids
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2001
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Centro Médico Nacional de Occidente/MX
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