Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
Biol. Res
;
34(2): 83-90, 2001. tab, graf
Article
in English
| LILACS
| ID: lil-303008
ABSTRACT
The biological characterization of bloodstream forms of eleven Trypanosoma cruzi cloned stocks, corresponding to two genetically similar clonets (19 and 20) and one distant clonet (39), according to multilocus enzyme electrophoresis analysis, showed dissimilar parasitemia in an experimental isogenic mouse model. While clonet 39 stocks gave low parasitemias, clonets 19 or 20 stocks gave high parasitemias, independently of the inocula (102 and 104 bloodstream forms) used. High parasitemia did not always associate with greater mortality. Statistical studies on mortality using a low inocula showed significantly higher mortality with clonet 39 stocks when compared to clonets 19 or 20 stocks. Finally, in order to confirm the identity of each stock studied, typing by molecular karyotype was performed before inoculating mice.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
Parasitemia
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2001
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
University of Chile/CL
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