Genetic polymorphism at position-308 in the promoter region of the tumornecrosis factor (TNF): implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population
Biol. Res
;
34(3/4): 237-241, 2001. tab
Article
in English
| LILACS
| ID: lil-303887
ABSTRACT
Several single-nucleotide polymorphisms have been identified in the human TNF gene promoter. The polymorphism at position-308 (TNF-308), which involves substituting G for A and designing the TNF2 allele, leads to a higher rate of TNF gene transcription than the wild-type TNF1 allele in in vitro expression studies. It has also been linked to increased susceptibility to a variety of illnesses. Using PCR-RFLP analysis we detected significant differences in the TNF-308 genotypes of Chilean and other populations. We conclude that there is a gradient in the distribution of the TNF2 allele according to ethnicity; we have also hypothesized that populations bearing a higher proportion of the TNF2 allele may have an increased predisposition toward or incidence of several chronic metabolic, degenerative, inflammatory and autoimmune diseases.
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Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Promoter Regions, Genetic
/
Tumor Necrosis Factor-alpha
/
Genetic Predisposition to Disease
/
Alleles
/
Gene Frequency
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
South America
/
Chile
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2001
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
University of Chile/CL
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