Efeitos da sibutramina no tratamento da obesidade em pacientes com hipertensão arterial / Effects of sibutramine on the treatment of obesity in patients with arterial hypertension
Arq. bras. cardiol
;
78(2): 172-180, Feb. 2002. tab, graf
Article
in Portuguese, English
| LILACS
| ID: lil-303902
ABSTRACT
OBJECTIVE:
To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months.METHODS:
The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo.RESULTS:
The group using sibutramine had a greater weight loss than that using placebo (6.7 percent versus 2.5 percent; p<0.001), an increase in heart rate (78.3±7.3 to 82±7.9 bpm; p=0.02), and a reduction in the left ventricular mass/height index (105±29.3 versus 96.6±28.58 g/m; p=0.002). Both groups showed similar increases in the levels of alkaline phosphatase and comparable adjustments in antihypertensive therapy; blood pressure, however, did not change.CONCLUSION:
The use of sibutramine caused weight loss and a reduction in left ventricular mass in obese and hypertensive patients with no interference with blood pressure or with antihypertensive therapy
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Appetite Depressants
/
Cyclobutanes
/
Hypertension
/
Obesity
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Female
/
Humans
/
Male
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Säo Paulo/BR
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