Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome
Arq. neuropsiquiatr
;
60(1): 28-31, Mar. 2002. ilus, tab
Article
in English
| LILACS, BVSAM
| ID: lil-304609
ABSTRACT
We report a case of a 49-year-old woman diagnosed with primary Sjögrens Syndrome (pSS) who was submitted to extensive neuropsychobiological assessment. Examination revealed a Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full Scale IQ of 97 with no Verbal/Performance IQ discrepancy and performance below estimated premorbid levels on arithmetic skills, visual tracking, naming and delayed paired associate learning/memory. CT scans of the brain were normal. However, there were subcortical hyperintensities on MRI and left parieto-temporal hypoperfusion on SPECT. Neuropsychological impairment is consistent with the pattern of neuroimage findings. We hypothesize that the pathophysiological mechanisms of pSS involve direct immune attack on neurons in addition to indirect effects through small-vessel angiopathy and thereby induce natural fracture lines in behavior according to location in the central nervous system
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sjogren's Syndrome
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2002
Type:
Article
/
Congress and conference
Affiliation country:
Brazil
Institution/Affiliation country:
Fundaçäo Oswaldo Cruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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