Effect of propafenone on the contractile activity of latissimus dorsi muscle isolated in an organ chamber: experimental study in rats / Efeito da propafenona na atividade contrátil do músculo Latissimus dorsi isolado em câmara de órgão. Estudo experimental em ratos
Arq. bras. cardiol
;
78(3): 299-308, Mar. 2002. ilus, tab, graf
Article
in English, Portuguese
| LILACS
| ID: lil-305036
ABSTRACT
OBJECTIVE:
To study the effect of propafenone on the contractile function of latissimus dorsi muscle isolated from rats in an organ chamber.METHODS:
We studied 20 latissimus dorsi muscles of Wistar rats and divided them into 2 groups group I (n=10), or control group - we studied the feasibility of muscle contractility; group II (n=10), in which the contralateral muscles were grouped - we analyzed the effect of propafenone on muscle contractility. After building a muscle ring, 8 periods of sequential 2-minute baths were performed, with intervals of preprogrammed electrical stimulation using a pacemaker of 50 stimuli/min. In group II, propafenone, at the concentration of 9.8 æg/mL, was added to the bath in period 2 and withdrawn in period 4.RESULTS:
In group I, no significant depression in muscle contraction occurred up to period 5 (p>0.05). In group II, a significant depression occurred in all periods, except between the last 2 periods (p<0.05). Comparing groups I and II only in period 1, which was a standard period for both groups, we found no significant difference (p>0.05).CONCLUSION:
Propafenone had a depressing effect on the contractile function of latissimus dorsi muscle isolated from rats and studied in an organ chamber
Full text:
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Index:
LILACS (Americas)
Main subject:
Propafenone
/
Muscle, Skeletal
/
Anti-Arrhythmia Agents
/
Muscle Contraction
Limits:
Animals
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundaçäo Cardiovascular Säo Francisco de Assis/BR
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