Importância da albumina sérica na avaliação nutricional e de atividade inflamatória em pacientes com doença de Crohn / Importance of serum albumin values in nutritional assessment and inflammatory activity in patients with Crohn's disease
Arq. gastroenterol
;
38(2): 104-108, abr.-jun. 2001. tab
Article
in Portuguese
| LILACS
| ID: lil-305365
RESUMO
BACKGROUND:
The serum albumin concentration has frequently been regarded as an indicator of nutritional status, although the hypoalbuminemia may reflect an acute phase protein response during inflammation mediated by cytokines. Both hypoalbuminemia and malnutrition are observed in Crohn's disease.OBJECTIVES:
To correlate the serum albumin values to disease activity and also to nutritional status in patients with Crohn's disease. PATIENTS/METHODS:
Thirty six patients were studied. Nutritional status was assessed by anthropometry measures and inflammatory activity determined by Harvey's simple clinical index and erythrocyte sedimentation rate.RESULTS:
No correlation was found between malnutrition and hypoalbuminemia. The serum albumin levels correlated inversely with the disease activity. Hypoalbuminemia was 100% sensitive for detection of disease activity.CONCLUSION:
This study suggests that serum albumin concentration is a very sensitive marker of inflammatory activity and not good indicator of the nutritional status in Crohn's disease. It is necessary a suitable laboratorial parameter for routine nutrition assessment in patients with this inflammatory bowel disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Serum Albumin
/
Crohn Disease
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Portuguese
Journal:
Arq. gastroenterol
Journal subject:
Gastroenterology
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de São Paulo/BR
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