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Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
Ferreras, Ana; Triana, Ledia; Sánchez, Erlinda; Herrera, Flor.
  • Ferreras, Ana; Universidad de Carabobo-Núcleo Aragua. Facultad de Ciencias de la Salud. Centro de Investigaciones Biomédicas. Aragua. VE
  • Triana, Ledia; Universidad de Carabobo-Núcleo Aragua. Facultad de Ciencias de la Salud. Centro de Investigaciones Biomédicas. Aragua. VE
  • Sánchez, Erlinda; Universidad de Carabobo-Núcleo Aragua. Facultad de Ciencias de la Salud. Centro de Investigaciones Biomédicas. Aragua. VE
  • Herrera, Flor; Universidad de Carabobo-Núcleo Aragua. Facultad de Ciencias de la Salud. Centro de Investigaciones Biomédicas. Aragua. VE
Mem. Inst. Oswaldo Cruz ; 97(3): 377-380, Apr. 2002. ilus, graf
Article in English | LILACS | ID: lil-307959
RESUMO
A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA
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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium falciparum / Protein Synthesis Inhibitors / Protozoan Proteins / Antimalarials Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2002 Type: Article Affiliation country: Venezuela Institution/Affiliation country: Universidad de Carabobo-Núcleo Aragua/VE

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Full text: Available Index: LILACS (Americas) Main subject: Plasmodium falciparum / Protein Synthesis Inhibitors / Protozoan Proteins / Antimalarials Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2002 Type: Article Affiliation country: Venezuela Institution/Affiliation country: Universidad de Carabobo-Núcleo Aragua/VE