In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil
Rev. Inst. Med. Trop. Säo Paulo
;
43(5): 267-270, Sept.-Oct. 2001. tab
Article
in English
| LILACS
| ID: lil-308000
ABSTRACT
The purpose of the present study was to compare the susceptibility to four antifungal agents of 69 Cryptococcus neoformans strains isolated from AIDS patients with that of 13 C. neoformans strains isolated from the environment. Based on the NCCLS M27-A methodology the Minimal Inhibitory Concentrations (MICs) obtained for amphotericin B, itraconazole and ketoconazole were very similar for clinical and environmental isolates. Clinical isolates were less susceptible to fluconazole than environmental isolates. The significance of these findings and aspects concerning the importance, role and difficulties of C. neoformans susceptibility testing are also discussed
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Index:
LILACS (Americas)
Main subject:
Cryptococcus neoformans
/
Antifungal Agents
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Universitário de Santa Maria/BR
/
Universidade Federal de Santa Maria/BR
/
Universidade Federal do Rio Grande do Sul/BR
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