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Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae)
Duarte, Lucienir Pains; Vieira Filho, Sidney Augusto; Silva, Grácia Divina de Fátima; Sousa, José Rego de; Pinto, Artur da Silveira.
Affiliation
  • Duarte, Lucienir Pains; UFMG. Departamento de Química. Núcleo de Estudo de Plantas Medicinais. BR
  • Vieira Filho, Sidney Augusto; UFMG. Departamento de Química. Núcleo de Estudo de Plantas Medicinais. BR
  • Silva, Grácia Divina de Fátima; UFMG. Departamento de Química. Núcleo de Estudo de Plantas Medicinais. BR
  • Sousa, José Rego de; UFMG. Departamento de Química. Núcleo de Estudo de Plantas Medicinais. BR
  • Pinto, Artur da Silveira; UFMG. Departamento de Microbiologia. Belo Horizonte. BR
Rev. Inst. Med. Trop. Säo Paulo ; Rev. Inst. Med. Trop. Säo Paulo;44(2): 109-112, Mar.-Apr. 2002. tab
Article in En | LILACS | ID: lil-308015
Responsible library: BR1.1
ABSTRACT
Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds
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Full text: 1 Index: LILACS Main subject: Triterpenes / Trypanocidal Agents / Trypanosoma cruzi Limits: Animals Language: En Journal: Journal of the São Paulo Institute of Tropical Medicine / Rev Inst Med Trop Sao Paulo / Rev. Inst. Med. Trop. São Paulo (Online) / Rev. Inst. Med. Trop. Säo Paulo / Revista do Instituto de Medicina Tropical de Säo Paulo (Impresso) Journal subject: MEDICINA TROPICAL Year: 2002 Type: Article
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Full text: 1 Index: LILACS Main subject: Triterpenes / Trypanocidal Agents / Trypanosoma cruzi Limits: Animals Language: En Journal: Journal of the São Paulo Institute of Tropical Medicine / Rev Inst Med Trop Sao Paulo / Rev. Inst. Med. Trop. São Paulo (Online) / Rev. Inst. Med. Trop. Säo Paulo / Revista do Instituto de Medicina Tropical de Säo Paulo (Impresso) Journal subject: MEDICINA TROPICAL Year: 2002 Type: Article