Cholinergic stimulation with pyridostigmine reduces the QTc interval in coronary artery disease
Braz. j. med. biol. res
;
35(6): 685-689, June 2002. ilus, tab
Article
in English
| LILACS
| ID: lil-309517
ABSTRACT
Parasympathetic dysfunction is an independent risk factor in patients with coronary artery disease; thus, cholinergic stimulation is a potential therapeutic measure that may be protective by acting on ventricular repolarization. The purpose of the present study was to determine the effects of pyridostigmine bromide (PYR), a reversible anticholinesterase agent, on the electrocardiographic variables, particularly QTc interval, in patients with stable coronary artery disease. In a randomized double-blind crossover placebo-controlled study, simultaneous 12-lead electrocardiographic tracings were obtained at rest from 10 patients with exercise-induced myocardial ischemia before and 2 h after the oral administration of 45 mg PYR or placebo. PYR increased the RR intervals (pre 921 ± 27 ms vs post 1127 ± 37 ms; P<0.01) and, in contrast with placebo, decreased the QTc interval (pre 401 ± 3 ms vs post 382 ± 3 ms; P<0.01). No other electrocardiographic variables were modified (PR segment, QT interval, QT and QTc dispersions). Cholinergic stimulation with PYR caused bradycardia and reduced the QTc interval without important side effects in patients with coronary disease. These effects, if confirmed in studies over longer periods of administration, may suggest a cardioprotection by cholinergic stimulation with PYR
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pyridostigmine Bromide
/
Cholinesterase Inhibitors
/
Coronary Disease
Type of study:
Controlled clinical trial
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2002
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Estadual de Cardiologia Aluísio de Castro/BR
/
Universidade Federal Fluminense/BR
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