Carbon dioxide test as an additional clinical measure of treatment response in panic disorder
Arq. neuropsiquiatr
;
60(2B): 358-361, June 2002.
Article
in English
| LILACS
| ID: lil-310850
ABSTRACT
OBJECTIVE:
We aim to determine if a treatment with a dose of clonazepam - 2 mg/day, for 6 weeks, blocks spontaneous panic attacks and the ones induced by the inhalation of 35 percent carbon dioxide (CO2) in panic disorder (PD) patients. The CO2 challenge-test may be a useful addition tool for measuring the pharmacological response during the initial phase (6 weeks) in the treatment of PD.METHOD:
Eighteen PD patients drug free for a week participated in a carbon dioxide challenge test. Fourteen had a panic attack and were openly treated for a 6-week period with clonazepam. At the end of the 6-week period they were submitted again to the CO2 challenge test.RESULTS:
After 6 weeks of treatment with clonazepam, 12 of 14 PD patients (85.7 percent) did not have a panic attack after the CO2 challenge test. Just 2 of 14 patients (14.3 percent) had a panic attack after the CO2 challenge test. Ten of 14 (71.4 percent) PD patients had panic free status after clonazepam treatment. The 2 patients who had a panic attack in the sixth week, after the CO2 test, did not have panic free status after the treatment with clonazepam.CONCLUSION:
The CO2-test may be a valid tool for testing and predicting the drug response
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Carbon Dioxide
/
Panic Disorder
/
Clonazepam
/
Anticonvulsants
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2002
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Rio de Janeiro/BR
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