Estudo dos efeitos da terapia de reposiçäo hormonal sobre a apoptose e a expressäo das proteínas bcl-2 e p53 em pele de mulheres pós menopáusicas / Studies of the effects of the hormonal therapy on apoptotic and to the expression of bcl-2 and p53 proteins in epidermis in post-menopausal women
Säo Paulo; s.n; 1999. 86 p.
Thesis
in Portuguese
| LILACS, SES-SP
| ID: lil-313074
RESUMO
Nineteen post-menopausal womens were aleatoryly divided into two groups, in accordance to use of placebo (Group A - nine women) or hormonal treatment (Group B ten women) during a six months period. The groups were studied as to the number of opoptotic cells and to the expression of bcl-2 and p53 proteins in epidermis biopsies carried out before and after treatment. Identification of apoptotic cells was obtained by TUNEL assay. bcl-2 and p53 expression was studied by immunocytochemistry techniques, by using monoclonal antibodies. Groups were homogeneous as to age and race; however, Group B showed a significantly longer menopausal period. Results have pointed out that hormonal therapy during six months did not influence signicantly in the number of apoptotic cells in the epidermis of post-menopausal women. Negative reactions to bcl-2 and p53 expression were observed in all the cases.
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Index:
LILACS (Americas)
Main subject:
Estrogen Replacement Therapy
/
Skin Aging
/
Tumor Suppressor Protein p53
/
Apoptosis
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
Language:
Portuguese
Year:
1999
Type:
Thesis
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