Evaluation of Gilles de la Tourette syndrome with [99mTc] HMPAO Brain SPECT
Rev. med. nucl. Alasbimn j
;
4(15)abr. 2002. ilus, tab
Article
in English
| LILACS
| ID: lil-313225
RESUMO
Gilles de la Tourette syndrome (GLTS) is a disorder characterized by tics and several behavioral disturbances. Although GLTS is a relatively common disorder, little is known about its pathophysiology. Previous studies with SPECT and PET were performed in a small number of patients and have shown some discordant data. The aim of this study is to evaluate brain perfusion abnormalities in patients with GLTS and to correlate them with the clinical manifestations of the syndrome. Twenty-eight patients were submitted to brain [99mTc]-HMPAO SPECT. 82 percent of the patients had abnormal studies. The most frequent finding was perfusion abnormalities in the thalami in 16 patients (57 percent) and 85 percent of patients with hyperperfusion of one or both thalami had complex motor tics. This investigation has demonstrated that brain perfusion SPECT is able to identify cortical perfusion abnormalities, associated with clinical symptoms in patients with GLTS. These abnormalities involve the pre-frontal-striatal-thalamic-cortical pathways
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tourette Syndrome
/
Tomography, Emission-Computed, Single-Photon
/
Technetium Tc 99m Exametazime
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Rev. med. nucl. Alasbimn j
Journal subject:
Nuclear Medicine
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Estado de Campinas/BR
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