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New enamine derivatives of lapachol and biological activity
Oliveira, Mailcar F; Lemos, Telma L. G; Mattos, Marcos C. de; Segundo, Taciana A; Santiago, Gilvandete M. P; Braz-Filho, Raimundo.
  • Oliveira, Mailcar F; Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza. BR
  • Lemos, Telma L. G; Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza. BR
  • Mattos, Marcos C. de; Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica. Fortaleza. BR
  • Segundo, Taciana A; Universidade Federal do Ceará. Departamento de Farmácia. Fortaleza. BR
  • Santiago, Gilvandete M. P; Universidade Federal do Ceará. Departamento de Farmácia. Fortaleza. BR
  • Braz-Filho, Raimundo; Universidade Estadual do Norte Fluminense. CCT. LCQUI. Setor de Química de Produtos Naturais. Campos. BR
An. acad. bras. ciênc ; 74(2): 211-221, June 2002. ilus, tab
Article in English | LILACS | ID: lil-314019
ABSTRACT
A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells
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Full text: Available Index: LILACS (Americas) Main subject: Naphthoquinones / Amines / Antineoplastic Agents, Phytogenic Limits: Animals / Female / Humans Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2002 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Norte Fluminense/BR / Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Naphthoquinones / Amines / Antineoplastic Agents, Phytogenic Limits: Animals / Female / Humans Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2002 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual do Norte Fluminense/BR / Universidade Federal do Ceará/BR