Lethal effect of the scorpion Tityus serrulatus venom: comparative study on adult and weanling rats

Nunan, Elzíria Aguiar; Cardoso, Valbert Nascimento; Moraes-Santos, Tasso

Nunan, Elzíria Aguiar; Cardoso, Valbert Nascimento; Moraes-Santos, Tasso.

Nunan, Elzíria Aguiar; Universidade Federal de Minas Gerais. Faculdade de Farmácia. BR
Cardoso, Valbert Nascimento; Universidade Federal de Minas Gerais. Faculdade de Farmácia. BR
Moraes-Santos, Tasso; Universidade Federal de Minas Gerais. Faculdade de Farmácia. BR

RBCF, Rev. bras. ciênc. farm. (Impr.) ; 37(1): 39-44, jan.-abr. 2001. tab, graf

Article in English | LILACS | ID: lil-314067

RESUMO

RESUMO

Scorpion sting accidents are common in Brazil and several lethal cases occur among children. This observation can be due to higher concentration of circulating venon in children. However, other factors such as those related to the growth and development of the organism might modulate differently children and adult envenomation. The present work aimed to compare acute toxicity, by median lethal doses (LD50) evaluation, using weanling male and female (21-22 days) and adult (150-160 days) rats, after subcutaneous injection with saline extract of crude venom. The LD50 values, expressed as mg of venom protein per kg of rat body weight, were calculated according to the statistical Probit method...

Subject(s)

Animals; Rats; Child; Child Development; Poisoning; Toxins, Biological; Scorpion Venoms/analysis; Scorpion Venoms/toxicity; Evaluation Study; Injections, Subcutaneous; Lethal Dose 50; Toxicity Tests

Search on Google

XML

Index: LILACS (Americas) Main subject: Poisoning / Scorpion Venoms / Toxins, Biological / Child / Child Development Limits: Animals Language: English Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: Biochemistry / Pharmacy / Pharmacology Year: 2001 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR

Similar

MEDLINE

LILACS

LIS

Search on Google

XML