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Antiulcer activity of the ethanol extract of Sesbania grandiflora
Sertié, Jayme Antônio Aboin; Wiezel, Guiomar; Woisky, Ricardo Gomide; Carvalho, José Carlos Tavares.
Affiliation
  • Sertié, Jayme Antônio Aboin; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. BR
  • Wiezel, Guiomar; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. BR
  • Woisky, Ricardo Gomide; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. BR
  • Carvalho, José Carlos Tavares; Universidade de Alfenas. Instituto de Farmácia e Nutrição. Laboratório de Fitofármacos. BR
RBCF, Rev. bras. ciênc. farm. (Impr.) ; RBCF, Rev. bras. ciênc. farm. (Impr.);37(1): 107-112, jan.-abr. 2001. tab, graf
Article in En | LILACS | ID: lil-314074
Responsible library: BR40.1
ABSTRACT
The ethanolic extract of the bark of S. grandiflora prevented acute gastric injury in rats. Stress and nonstereoidal antiinflammatory drugs-induced lesions were significantly prevented by the extract. At a dosis of 36.75 mg/kg (ED50, p.o.) the extract did not modify the volume, pH and hydrochloric acid contents of gastric secretion. At the doses used the animals had no depressive, excitatory or sleepness symptoms, suggesting that problably centrally acting components involved in antiulcer action are not found in the extract. The results suggest that S. grandiflora has antiulcer potential...
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Index: LILACS Main subject: Plants, Medicinal / Stomach Ulcer / Anti-Inflammatory Agents, Non-Steroidal Limits: Animals Language: En Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2001 Type: Article
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Index: LILACS Main subject: Plants, Medicinal / Stomach Ulcer / Anti-Inflammatory Agents, Non-Steroidal Limits: Animals Language: En Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2001 Type: Article