Preoperative serum levels of ca 72-4, cea, ca 19-9, and Alpha-fetoprotein in patients with gastric cancer
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
57(3): 89-92, May-June 2002.
Article
in English
| LILACS
| ID: lil-314469
ABSTRACT
INTRODUCTION:
The clinical importance of preoperative serum levels of CA 72-4, carcinoembryonic antigen (CEA), CA 19-9, and alpha-fetoprotein (AFP) was prospectively evaluated in 44 patients with gastric cancer.METHOD:
The serum tumor marker levels were determined by commercial radioimmunoassay kits. Positivity for CA 72-4 (>4 U/mL), CEA (>5 ng/mL), CA 19-9 (>37 U/mL), and AFP (>10 ng/mL) were correlated according to the stage, histology, and lymph node metastasis. RESULTS ANDDISCUSSION:
CA 72-4 showed a higher positivity rate for gastric cancer (47.7 percent) than CEA (25 percent), CA 19-9 (25 percent), and AFP (0 percent). The combination of CA 72-4 with CEA and CA 19-9 increased the sensitivity to 61.4 percent. The positivity rates of CA 72-4 in patients at stages I and II (initial disease) and in patients at stages III and IV (advanced disease) were 9 percent and 60.6 percent, respectively (P < 0.005). No correlation was found between CEA and CA 19-9 levels and the stage of gastric cancer. There was a tendency of positivity for CA 72-4 to suggest lymph node involvement, but it was not significant (P = 0.075). Serum levels of tumor markers did not show a correlation with the histological types of gastric cancer.CONCLUSION:
Preoperative serum levels of CA 72-4 provided a predictive value in indicating advanced gastric cancer
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stomach Neoplasms
/
Biomarkers, Tumor
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Journal subject:
Medicine
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Säo Paulo/BR
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