Lack of correlation between seminal and plasma HIV-1 viral loads is associated with CD4T cell depletion in therapy-naïve HIV-1+ patients
Mem. Inst. Oswaldo Cruz
;
97(4): 563-567, June 2002. tab, graf
Article
in English
| LILACS
| ID: lil-314523
ABSTRACT
The present study was conducted to investigate a possible correlation between plasma (PVL) and seminal viral load (SVL) on treatment-naïve HIV-1-infected patients in Vitória, ES, Brazil. We also evaluated whether the progressive immunosuppression associated with HIV disease (as evidenced by declining CD4 T cell counts) has any impact on the correlation between PVL and SVL HIV-1. Viral load on paired blood and semen samples from 56 consecutive treatment-naïve patients were evaluated and compared to CD4 cell counts. Viral load and T cell counts (cells/æl) were determined by NASBA and by flow cytometry, respectively. Overall, a strong positive correlation between PVL and SVL (rho = 0.438, p = 0.001) was observed. However, when patients were grouped according to their CD4 counts, this correlation was only significant among patients with CD4 counts > 200 cells/æl. Results presented here demonstrate the existence of a strong correlation between PVL and SVL on patients with CD4 cell counts > 200 cells/æl, suggesting that this association may correlate with disease progression
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Semen
/
HIV Infections
/
Lymphocyte Depletion
/
Viral Load
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Santa Casa de Misericordia de Vitoria/BR
/
Universidade Federal do Espírito Santo/BR
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