Cardiac damage from chronic use of chloroquine: a case report and review of the literature
Arq. bras. cardiol
;
79(1): 85-88, July 2002. ilus
Article
in English
| LILACS
| ID: lil-316169
RESUMO
Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Chloroquine
/
Heart Diseases
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Säo Paulo/BR
Similar
MEDLINE
...
LILACS
LIS