Six years of treatment with the HELP system of a patient with familial hypercholesterolemia
Braz. j. med. biol. res
;
35(7): 775-782, July 2002. ilus, graf
Article
in English
| LILACS
| ID: lil-316739
RESUMO
The purpose of the present report is to demonstrate the long-term efficacy and safety of heparin-induced extracorporeal lipoprotein precipitation (HELP) of LDL-c and fibrinogen in the management of familial hypercholesterolemia. From June 1992 to June 1998 a 22-year-old young male patient with familial hypercholesterolemia (double heterozygote for C660X and S305C) resistant to medication and diet and with symptomatic coronary artery disease (angina) was treated weekly with 90-min sessions of the HELP system. The patient had also been previously submitted to right coronary artery angioplasty. The efficacy of the method was evaluated by comparing the reduction of total cholesterol, LDL-c and fibrinogen before and after the sessions and before and after initiation of the study (data are reported as averages for each year). During the study, angina episodes disappeared and there were no detectable adverse effects of the treatment. Total cholesterol (TC), fibrinogen, and LDL-c decreased significantly after each session by 59.6, 66.1 and 64 percent, respectively. HDL-c showed a nonsignificant reduction of 20.4 percent. Comparative mean values pre- and post-treatment values in the study showed significant differences: TC (488 vs 188 mg/dl), LDL-c (416.4 vs 145 mg/dl), and fibrinogen (144.2 vs 57.4 mg/dl). There was no significant change in HDL-c level: 29.4 vs 23 mg/dl. These data show that the HELP system, even for a long period of time, is a safe and efficient mode of treatment of familial hypercholesterolemia and is associated with disappearance of angina symptoms
Full text:
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Index:
LILACS (Americas)
Main subject:
Heparin
/
Hyperlipoproteinemia Type II
/
Cholesterol, LDL
/
Anticoagulants
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade Evangélica de Medicina do Paraná/BR
/
Hospital Universitário Evangélico de Curitiba/BR
/
Universidade de Säo Paulo/BR
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