Contribuição dos depósitos hepáticos de imunoglobulina A no diagnóstico da hepatopatia alcoólica / Contribution of hepatic immunoglobulin A deposits to the diagnosis of alcoholic hepatopathy
Arq. gastroenterol
;
38(3): 162-167, jul.-set. 2001. tab
Article
in Portuguese
| LILACS
| ID: lil-317311
RESUMO
BACKGROUND:
Alcoholic hepatic disease is a severe and frequent disease and its diagnosis is not always an easy task.AIM:
To assess the contribution of immunoglobulin A (IgA) in the hepatic sinusoids for diagnosis of alcoholic hepatopathy. PATIENTS ANDMETHODS:
The presence of IgA was studied through direct immunofluorescence in 59 patients submitted to hepatic needle biopsy, indicated by clinical or in vitro changes suggestive of chronic hepatopathy.RESULTS:
A significant deposition of IgA was found in alcoholic patients as compared to non-alcoholic patients, with 76% sensitivity (95% CI 54.5-89.8) and 73.5% specificity (95% CI 55.3-86.5). In individuals who present only alcohol as the etiological agent of hepatopathy, compared with the subgroup of B or C virus carriers, the results were even more significant, with 85.7% sensitivity (95% CI 56.2-97.5) and 89.5% specificity (95% CI 65.5-98.2).CONCLUSION:
The deposition of IgA in the hepatic sinusoids present sensitivity and specificity for the diagnosis of an alcohol-induced hepatic lesion. This resource can be particularly useful when conventional histology can not be define a specific cause for the change found
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Immunoglobulin A
/
Liver
/
Liver Diseases, Alcoholic
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Portuguese
Journal:
Arq. gastroenterol
Journal subject:
Gastroenterology
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Departamento de Medicina Interna/BR
/
Pontifícia Universidade Católica do Rio Grande do Sul/BR
/
Universidade Federal do Rio Grande do Sul/BR
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