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Neurohypophyseal hormones and atrial natriuretic peptide in the control of body fluid homeostasis
Elias, L. L. K; Castro, M; Valença, M. M; McCann, S. M; Antunes-Rodrigues, J.
  • Elias, L. L. K; USP. Department of Physiology. BR
  • Castro, M; USP. Department of Physiology. BR
  • Valença, M. M; Federal University of Pernambuco. Department of Neuropsychiatry. BR
  • McCann, S. M; Pennington Biomedical Research Center. Lousiana. US
  • Antunes-Rodrigues, J; USP. Department of Physiology. BR
ARBS annu. rev. biomed. sci ; 3: 5-47, 2001. graf
Article in English | LILACS | ID: lil-318756
ABSTRACT
Mammals control the volume and osmolality of their body fluids by stimuli that arise from both the intracellular and extracellular fluid compartments. These stimuli are sensed by two kinds of receptors osmoreceptor-Na+-receptors (plasma osmolality or sodium concentration) and volume or pressure receptors. This information is conveyed to specific areas of the central nervous system responsible for an integrative response, which depends on the integrity of the anteroventral region of the third ventricle, e.g. organum vasculosum of the lamina terminalis, median preoptic nucleus, and subfornical organ. In addition, the paraventricular, supraoptic and suprachiasmatic nuclei are also important structures involved in hydromineral balance. The hypothalamo-neurohypophyseal system plays a fundamental role in the maintenance of body fluid homeostasis by secreting vasopressin and oxytocin in response to osmotic and non-osmotic stimuli. The natriuretic factor in the heart, which is released by the distension of the atria, leading to natriuresis and a myorelaxing action on vascular smooth muscle, also contributes to the hydromineral balance. In addition to the natriuretic factor in the heart, the identification of a natriuretic factor in the central nervous system mediating natriuresis was also demonstrated by purification of hypothalamic extracts. Therefore, the presence of the natriuretic factor in the heart and in the central nervous system allowed the characterization of a neuroendocrine system controlling body fluid homeostasis.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Peptides / Atrial Natriuretic Factor / Receptors, Atrial Natriuretic Factor / Arterial Pressure / Homeostasis / Hypothalamo-Hypophyseal System Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: ARBS annu. rev. biomed. sci Journal subject: Biology Year: 2001 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Federal University of Pernambuco/BR / Pennington Biomedical Research Center/US / USP/BR

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Full text: Available Index: LILACS (Americas) Main subject: Peptides / Atrial Natriuretic Factor / Receptors, Atrial Natriuretic Factor / Arterial Pressure / Homeostasis / Hypothalamo-Hypophyseal System Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: ARBS annu. rev. biomed. sci Journal subject: Biology Year: 2001 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Federal University of Pernambuco/BR / Pennington Biomedical Research Center/US / USP/BR