Studies on the replication of Mayaro virus grown in interferon treated cells

Rebello, M. C. S; Fonseca, M. E. F; Marinho, J. O; Rebello, M. A

Rebello, M. C. S; Fonseca, M. E. F; Marinho, J. O; Rebello, M. A.

Affiliation

Rebello, M. C. S; Universidade Federal do Rio de Janeiro (UFRJ). Centro de Ciéncias de Saúde. Instituto de Microbiologia. BR
Fonseca, M. E. F; Universidade Federal do Rio de Janeiro (UFRJ). Centro de Ciéncias de Saúde. Instituto de Microbiologia. BR
Marinho, J. O; Universidade Federal do Rio de Janeiro (UFRJ). Centro de Ciéncias de Saúde. Instituto de Microbiologia. BR
Rebello, M. A; Universidade Federal do Rio de Janeiro (UFRJ). Centro de Ciéncias de Saúde. Instituto de Microbiologia. BR

Mem. Inst. Oswaldo Cruz ; 89(4): 619-623, Oct.-Dec. 1994.

Article in En | LILACS | ID: lil-319929

Responsible library: BR1.1

RESUMO

RESUMO

Mayaro virus grown in interferon treated infected cells has been characterized with regard to its ability to replicate in vertebrate (TC7) and invertebrate (Aedes albopictus) cells. Virus purified from interferon treated TC7 cells adsorbs and penetrates to the same extent as the control virus. During infection, these virus particles caused inhibition of host protein synthesis and synthesized the same spectrum of viral proteins as normal virus. This population however, was apparently more sensitive to interferon treatment. Electron microscopy of TC7 cells showed the presence of numerous aberrant virus particles budding from the plasma membrane.

Subject(s)

Animals; Alphavirus; Interferon-alpha; Virus Replication/drug effects; Aedes; Alphavirus; Electrophoresis, Polyacrylamide Gel; Interferon-alpha; Viral Proteins/biosynthesis

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Full text: 1 Index: LILACS Main subject: Virus Replication / Interferon-alpha / Alphavirus Limits: Animals Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 1994 Type: Article

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