A novel merozoite surface antigen of Plasmodium falciparum (MSP-3) identified by cellular-antibody cooperative mechanism antigenicity and biological activity of antibodies
Mem. Inst. Oswaldo Cruz
;
89(Suppl.2): 77-80, 1994.
Article
in English
| LILACS
| ID: lil-319946
RESUMO
We report the identification of a 48kDa antigen targeted by antibodies which inhibit Plasmodium falciparum in vitro growth by cooperation with blood monocytes in an ADCI assay correlated to the naturally acquired protection. This protein is located on the surface of the merozoite stage of P. falciparum, and is detectable in all isolates tested. Epidemiological studies demonstrated that peptides derived from the amino acid sequence of MSP-3 contain potent B and T-cell epitopes recognized by a majority of individuals living in endemic areas. Moreover human antibodies either purified on the recombinant protein, or on the synthetic peptide MSP-3b, as well as antibodies raised in mice, were all found to promote parasite killing mediated by monocytes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium falciparum
/
Immunoglobulin M
/
Protozoan Proteins
/
Antigens, Surface
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1994
Type:
Article
Affiliation country:
France
Institution/Affiliation country:
Institut Pasteur/FR
Similar
MEDLINE
...
LILACS
LIS