Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase
Mem. Inst. Oswaldo Cruz
;
89(Suppl.2): 47-49, 1994.
Article
in English
| LILACS
| ID: lil-319952
ABSTRACT
Numerous proteinase activities have been shown to be essential for the survival of Plasmodium falciparum. One approach to antimalarial chemotherapy, would be to block specifically one or several of these activities, by using compounds structurally analogous to the substrates of these proteinases. Such a strategy requires a detailed knowledge of the active site of the proteinase, in order to identify the best substrate for the proteinase. Aiming at developing such a strategy, two proteinases previously identified in our laboratory, were chosen for further characterization of their molecular structure and properties: the merozoite proteinase for erythrocytic invasion (MPEI), involved in the erythrocyte invasion by the merozoites, and the Pf37 proteinase, which hydrolyses human spectrin in vitro.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Endopeptidases
/
Plasmodium falciparum
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1994
Type:
Article
Affiliation country:
France
Institution/Affiliation country:
CNRS/FR
/
Institut Pasteur/FR
/
Laboratoire de Biologie Parasitaire et Chimiothérapie/FR
/
Laboratorie de Pathologie Cellulaire et Moleculaire en Hematologie/FR
Similar
MEDLINE
...
LILACS
LIS