Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera

Roeffen, W; Lensen, T; Mulder, B; Teelen, K; Sauerwein, R; Eling, W; Meuwissen, J. H; Beckers, P

Roeffen, W; Lensen, T; Mulder, B; Teelen, K; Sauerwein, R; Eling, W; Meuwissen, J. H; Beckers, P.

Affiliation

Roeffen, W; University of Nijmegen. Department of Medical Microbiology. NL
Lensen, T; University of Nijmegen. Department of Medical Microbiology. NL
Mulder, B; University of Nijmegen. Department of Medical Microbiology. NL
Teelen, K; University of Nijmegen. Department of Medical Microbiology. NL
Sauerwein, R; University of Nijmegen. Department of Medical Microbiology. NL
Eling, W; University of Nijmegen. Department of Medical Microbiology. NL
Meuwissen, J. H; University of Nijmegen. Department of Medical Microbiology. NL
Beckers, P; University of Nijmegen. Department of Medical Microbiology. NL

Mem. Inst. Oswaldo Cruz ; 89(Suppl.2): 13-15, 1994.

Article in En | LILACS | ID: lil-319960

Responsible library: BR1.1

ABSTRACT

ABSTRACT

Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55 of the sera blocking in the bio-assay gave positive results in these competition ELISA's.

Subject(s)

Humans; Adult; Antibodies, Protozoan/immunology; Antigens, Surface/immunology; Enzyme-Linked Immunosorbent Assay; Immune Sera; Malaria, Falciparum

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Full text: 1 Index: LILACS Main subject: Enzyme-Linked Immunosorbent Assay / Antibodies, Protozoan / Malaria, Falciparum / Immune Sera / Antigens, Surface Limits: Adult / Humans Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 1994 Type: Article

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