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Factores de crecimiento y oncogenes en adenocarcinomas mamarios inducidos por acetato de medroxyprogesterona en ratones BALB/c / Growth hormones and oncogenes in mammary adenocarcinomas induced by medroxyprogesterone acetate in BALB/c mice
Elizalde, Patricia V; Balaña, Maria Eugenia; Charreau, Eduardo H.
  • Elizalde, Patricia V; Instituto de Biología y Medicina Experimental. Buenos Aires. AR
  • Balaña, Maria Eugenia; Instituto de Biología y Medicina Experimental. Buenos Aires. AR
  • Charreau, Eduardo H; Instituto de Biología y Medicina Experimental. Buenos Aires. AR
Medicina (B.Aires) ; 57(Supl.2): 70-74, Aug. 1997.
Article in Spanish | LILACS | ID: lil-320008
ABSTRACT
We have studied the involvement of growth factors (GF), their receptors (GF-R) and oncogenes in modulating tumor growth in the medroxyprogesterone acetate (MPA)-induced mammary tumor model in BALB/c mice. We demonstrated the presence of both ligands of the insulin-like growth factor family (IGF-I, IGF-II) and the two types of receptors (IGF-RI, IGF-RII). MPA upregulated IGF-II mRNA and protein levels in hormone-dependent lines (MPA-D). The progression to a hormone-independent phenotype was accompanied by a high constitutive expression of IGF-II and by a significant decrease in IGF-IIR number. An antisense strategy used to evaluate the role of IGF in the MPA-induced growth of epithelial MPA-D cells showed that IGF mediate progestin-induced mammary tumor growth by autocrine/intracrine pathways. We also studied the role of heregulins (HRG), the recently identified ligands for the c-erbB3 and c-erbB4 oncogenes. HRG mRNA expression was restricted to tumors of ductal origin. MPA induced an in vivo up-regulation of HRG expression. Finally, we also found that MPA may be exerting its proliferative effect on MPA-D lines by inhibiting the expression of transforming growth factor beta 1, (TGF-beta 1) and the lack of expression of TGF-beta 1 in hormone-independent tumors may be related to the acquisition of autonomous growth.
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Index: LILACS (Americas) Main subject: Oncogenes / Adenocarcinoma / Cell Transformation, Neoplastic / Growth Substances / Receptors, Growth Factor / Mammary Neoplasms, Experimental Type of study: Prognostic study Limits: Animals Language: Spanish Journal: Medicina (B.Aires) Journal subject: Medicine Year: 1997 Type: Article Affiliation country: Argentina Institution/Affiliation country: Instituto de Biología y Medicina Experimental/AR

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Index: LILACS (Americas) Main subject: Oncogenes / Adenocarcinoma / Cell Transformation, Neoplastic / Growth Substances / Receptors, Growth Factor / Mammary Neoplasms, Experimental Type of study: Prognostic study Limits: Animals Language: Spanish Journal: Medicina (B.Aires) Journal subject: Medicine Year: 1997 Type: Article Affiliation country: Argentina Institution/Affiliation country: Instituto de Biología y Medicina Experimental/AR