Lesão pulmonar na pancreatite aguda. Influência da redução do conteúdo enzimático do pâncreas / Lung injury in acute pancreatitis. Influence of pancreatic enzymes reduction
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
51(2): 37-43, Mar.-Apr. 1996.
Article
in Portuguese
| LILACS
| ID: lil-320231
ABSTRACT
A previous report has show that cerulein in physiological doses reduces the rate mortality of pancreatitis by decreasing the enzyme content of the pancreas. Clinically detectable signs of lung injury develop in up to 50-70 percent of patients with acute pancreatitis. The aim of the present study was to assess the effect of acute reduction of pancreatic enzyme content on the pancreatitis pulmonary injury. Experimental haemorrhagic pancreatitis was induced by intraductal injection of 5 per cent sodium taurocholate in two groups of Wistar rats group I (pancreatitis) and group II (pancreatitis after decreasing pancreatic enzyme content). Dye Evans blue was used to evaluate the lung injury. The degree of histologically observed lesions were similar in both groups, but the pulmonary lesion was smaller in group II than group I (p < 0.05). In conclusion:
1) pancreatitis' pulmonary lesion may be related with pancreatic enzymes that reach the blood stream and 2) the reduction of the pancreatic enzyme content has a beneficial effect on acute pancreatitis and reduces its pulmonary injury.
Search on Google
Index:
LILACS (Americas)
Main subject:
Pancreas
/
Pancreatitis
/
Lung
Limits:
Animals
Language:
Portuguese
Journal:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Journal subject:
Medicine
Year:
1996
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
Similar
MEDLINE
...
LILACS
LIS