Salvado de trigo y cáncer de mama: revisitando la hipótesis del estrógeno / Wheat bran and breast cancer: revisiting the estrogen hypothesis
Arch. latinoam. nutr
;
49(4): 309-317, Dec. 1999.
Article
in Spanish
| LILACS
| ID: lil-320285
ABSTRACT
Breast cancer is the most relevant form of cancer among women in Latin America. Many studies have evaluated the hormonal mechanisms involved in mammary carcinogenesis, although new focus is aimed towards factors that can potentially be used individually to reduce risk. Wheat bran seems to show a consistent protective effect in mammary carcinogenesis. Wheat bran, besides high level of insoluble fiber, also contains phytic acid and lignins, phytochemicals that have shown to inhibit in vitro and in vivo growth of mammary cancer. The protective effect of wheat bran in breast carcinogenesis is greatest at the promotional phase and when supplemented to a high fat diet. Doses of wheat bran in the 9-12range have been consistently protective and the inconsistencies observed at higher doses may be dependent on the animal model used. This review examines the protective role of wheat bran in the development of breast cancer and the possible mechanisms involved.
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Index:
LILACS (Americas)
Main subject:
Triticum
/
Breast Neoplasms
/
Dietary Fiber
/
Estrogens
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Female
/
Humans
Language:
Spanish
Journal:
Arch. latinoam. nutr
Journal subject:
Bioqu¡mica
/
EducaÆo Alimentar e Nutricional
/
Fenmenos Fisiol¢gicos da NutriÆo
/
Microbiologia de Alimentos
/
NUTRICAO
Year:
1999
Type:
Article
Affiliation country:
Canada
Institution/Affiliation country:
University of Toronto/CA
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