Comparação entre homens e mulheres hipercolesterolêmicos de alto risco de desenvolvimento de aterosclerose. Estudo dos fatores de risco e da resposta ao tratamento com pravastatina / Comparison of hypercholesterolemic men and women at high risk for atherosclerosis. Study of risk factors and response to pravastatin treatment

ABSTRACT

PURPOSE: To compare the prevalence of risk factors, and the response to pravastatin treatment between men and women. METHODS: We evaluated 486 men and 386 women, of these 230 men and 187 women received 10 mg of pravastatin for three months. RESULTS: There were differences between women and men in respectively arterial hypertension (45.5vs 40.8; p = 0.0012), left ventricular hypertrophy (33.0vs 22.0; p = 0.0041), sedentarism (94.8vs 87.8; p = 0.0005), smoking (43.0vs 61.8; p < 0.0001), Framingham scores (20.0 +/- 7.1 vs 16.0 +/- 7.6 p < 0.0001), HDL-C (43.0 +/- 11.0 vs 38.0 +/- 9.0 mg/dL; p 0.001), triglycerides-TG (216.0 +/- 115.0 vs 271.0 +/- 172.0 mg/dL; p < 0.001) and Castelli's indexes (CI) I and II (7.7 +/- 2.6 vs 8.6 +/- 3.2; p = 0.002 and 5.0 +/- 1.5 vs 5.5 +/- 2.0; p = 0.015). In men under pravastatin treatment there was a greater reduction in TG (32.0 vs 21.0p < 0.05) and CI I (-41.0vs -37.0; p < 0.05) and II (-40.0vs -38.0; p < 0.05). CONCLUSION: Men and women differed in risk factors prevalence and response to treatment with pravastatin.