Reduced schedule of human anti-rabies immunization with Fuenzalida & Palacios vaccine. Additional data
Rev. Inst. Med. Trop. Säo Paulo
;
35(3): 281-284, May-Jun. 1993.
Article
in English
| LILACS, SES-SP
| ID: lil-320585
ABSTRACT
It was reevaluated a reduced schedule for anti-rabies post-exposure immunization with newborn mice nervous tissue vaccine (Fuenzalida & Palacios) in a group of 30 non exposed volunteers. The vaccine was administered by intramuscular injections on days zero, 2, 4, 16 and 27, in the deltoid area. Antibody levels were determinated by a simplified serum neutralization microtest on days zero, 16 and 37. On days 16 and 37 the antibody levels of the whole group was > or = 0.5 IU/ml and > or = 1.0 IU/ml, respectively. The cell mediated immunity was precociously detected (on day 4) by the delayed type hypersensitivity skin test. Our results show that this reduced schedule elicited an early and effective humoral and cellular immune response. However it is necessary other studies with larger groups of vaccinees in order to obtain definitive conclusion.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Rabies
/
Rabies Vaccines
/
Immunization Schedule
Limits:
Adolescent
/
Adult
/
Humans
/
Male
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Year:
1993
Type:
Article
Institution/Affiliation country:
Instituto Pasteur de São Paulo/BR
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