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Immunization against hepatitis B in children from endemic zone: evaluation of the antibody response against the DNA recombinant vaccine (Engerix B-20 MCG)
Ferreira, C. R. R.
  • Ferreira, C. R. R; Instituto Oswaldo Cruz-FIOCRUZ. Departamento de Virologia. Rio de Janeiro. BR
Rev. Inst. Med. Trop. Säo Paulo ; 35(1): 89-92, Jan.-Fev. 1993.
Article in English | LILACS | ID: lil-320595
ABSTRACT
A previous seroepidemiological study in the rural zone of Vargem Alta (ES) SouthEast of Brazil, showed a prevalence of up to 9 of hepatitis B surface antigen (HBsAg) in some areas. One hundred susceptible children aging 1 to 5 years old were selected and immunized with a recombinant DNA hepatitis B vaccine (Smith-Kline 20 mcg) using the 0-1-6 months vaccination schedule. Blood samples were collected at the time of the first vaccine dose (month 0) in order to confirm susceptible individuals and 1,3,6 and 8 months after the first dose, to evaluate the antibody response. Our results showed that two and five months after the second dose, 79 and 88 of children seroconverted respectively, reaching 97 after the third dose. The levels of anti-HBs were calculated in milli International Units/ml (mIU/ml) and demonstrated the markedly increase of protective levels of antibodies after the third dose. These data showed a good immunogenicity of the DNA recombinant hepatitis B vaccine when administered in children of endemic areas.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Vaccines, Synthetic / Immunization / Hepatitis B Vaccines / Hepatitis B Type of study: Risk factors Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 1993 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Oswaldo Cruz-FIOCRUZ/BR

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Full text: Available Index: LILACS (Americas) Main subject: Vaccines, Synthetic / Immunization / Hepatitis B Vaccines / Hepatitis B Type of study: Risk factors Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: Rev. Inst. Med. Trop. Säo Paulo Journal subject: Tropical Medicine Year: 1993 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Oswaldo Cruz-FIOCRUZ/BR