Comprometimento da medula óssea e eosinofilia na paracoccidioidomicose / Bone marrow involvement and eosinophilia in paracoccidioidomycosis
Rev. Inst. Med. Trop. Säo Paulo
;
34(2): 85-90, Mar.-Apr. 1992.
Article
in Portuguese
| LILACS
| ID: lil-320613
RESUMO
The authors described three acute paracoccidioidomycosis patients with bone marrow involvement. P. brasiliensis yeast forms were observed in bone marrow smears of all them, and in one case, culture also revealed fungus growth. The mononuclear phagocytic system involvement, the blood eosinophilia and the negative skin hypersensibility responses were emphasized in all of them, as well as the severity of the disease in one case, with disseminated bone lesions and 20.260 eosinophils/mm3 in peripheral blood. The authors discuss the possible role of eosinophil in the host-parasite interaction in paracoccidioidomycosis, suggesting that TH 2 subpopulation activation and increased IL 5 and GM-CSF secretions may be responsible by eosinophilia in the most severe case.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Paracoccidioidomycosis
/
Bone Marrow
/
Eosinophilia
Limits:
Adolescent
/
Adult
/
Humans
Language:
Portuguese
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
1992
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
Similar
MEDLINE
...
LILACS
LIS