Avaliação da atividade terapêutica do itraconazol nas infecçoes crônicas, experimental e humana, pelo Trypanosoma cruzi / Evaluation of the therapeutic activity of itraconazole in chronic infections, experimental and human, by Trypanosoma cruzi
Rev. Inst. Med. Trop. Säo Paulo
;
34(2): 177-180, Mar.-Apr. 1992.
Article
in Portuguese
| LILACS
| ID: lil-320615
RESUMO
Other authors have demonstrated that itraconazole has antiparasitic activity against Trypanosoma cruzi both in vitro and in animal acute infection. Because of these observations, we decided to evaluate the chronic phase of this protozoal disease, since it is the most important form under a clinical and assistential point of view. We studied an infected mouse model as well as human cases of Chagas' disease. One hundred mg/kg/day by gastric tube, and 100 or 200 mg/day orally were given, respectively, during three months, without showing any beneficial effect, at least with the adopted methods.
Full text:
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Index:
LILACS (Americas)
Main subject:
Chagas Disease
/
Itraconazole
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Portuguese
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
1992
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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