Hepatitis B vaccine--proposal for a standardized assessment of immune response
Rev. Inst. Med. Trop. Säo Paulo
;
34(2): 137-140, Mar.-Apr. 1992.
Article
in English
| LILACS
| ID: lil-320621
ABSTRACT
The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intramuscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzyme immunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hepatitis B Vaccines
/
Hepatitis B Antibodies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
1992
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Escola Paulista de Medicina/BR
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