ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus
São Paulo med. j
;
120(2): 55-58, Mar. 2002. tab
Article
in English
| LILACS
| ID: lil-320716
RESUMO
CONTEXT Epidemiological studies have demonstrated higher frequencies of the O blood group and the non-secretor phenotype of ABH antigens among patients suffering from peptic ulcers. Since Helicobacter pylori has been established as the main etiological factor in this disease, controversies about the associations of the ABO and Lewis blood group phenotypes and secretor and non-secretor phenotypes in relation to susceptibility towards infection by this bacillus have been presented. OBJECTIVE:
To verify the frequencies of ABO, Lewis blood group phenotypes, secretor and non-secretor phenotypes in patients infected or uninfected by H. pylori.DESIGN:
Cross-sectional study.SETTING:
Outpatient clinic.PARTICIPANTS:
One hundred and twenty patients with dyspeptic symptoms who underwent endoscopy.MAIN MEASUREMENTS ABO and Lewis blood group phenotypes were determined by a standard hemagglutination test and the secretor and non-secretor phenotypes were evaluated by saliva samples using the inhibitor hemagglutination test.RESULTS:
The diagnosis of infection, made via breath and urea tests and confirmed using polymerase chain reaction (PCR) in gastric biopsy fragments, showed the presence of H. pylori in 61.7 percent of the patients and absence in 38.3 percent. The differences between the frequencies of the ABO blood group phenotypes among infected (A 27.0 percent; B 12.2 percent; AB 4.0 percent and O 56.8 percent) and uninfected patients (A 58.7 percent; B 13.0 percent; AB 4.3 percent and O 24.0 percent) were significant. The Lewis blood type, secretor and non-secretor phenotypes showed homogeneous distribution between the groups of patients analyzed.CONCLUSIONS:
Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes
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Index:
LILACS (Americas)
Main subject:
ABO Blood-Group System
/
Helicobacter pylori
/
Helicobacter Infections
/
Dyspepsia
/
Lewis Blood Group Antigens
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2002
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculty of Medicine of Säo José do Rio Preto/BR
/
Hemocenter of Säo José do Rio Preto/BR
/
Säo Paulo State University/BR
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