Efecto de la vitamina E, DL alfa-tocoferol, sobre el daño cromosómico en linfocitos de pacientes con ataxia telangiectasia / Effect of vitamin E, DL alfa-tocopherol, on chromosomal damage in lymphocytes from patients with ataxia telangiectasia
Rev. méd. Chile
;
130(9): 957-963, sept. 2002. tab
Article
in Spanish
| LILACS
| ID: lil-323228
ABSTRACT
Background:
In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an increment of chromosomal damage in A-T cells.Aim:
To study the in vitro effect of vitamin E (DL-a-tocopherol) on the frequency of chromosomal damage of lymphocytes from patients with A-T. Patients andmethods:
Seven patients with A-T and age-sex matched controls were studied. Chromosomal damage in mitosis was evaluated in lymphocytes cultures both under basal conditions and when G2 repair was prevented by 5 mM caffeine.Results:
In cells from patients with A-T, vitamin E induced a 57.1 and 47.9 percent decrease in chromosomal damage under basal and inhibited G2 repair conditions, respectively. However, there was a non significant improvement in their repair activity. Vitamin E effects on chromosomal damage was not significant in control subjects.Conclusions:
Vitamin E reduces chromosomal damage in lymphocytes from patients with ataxia telangiectasia
Full text:
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Index:
LILACS (Americas)
Main subject:
Vitamin E
/
In Vitro Techniques
/
Ataxia Telangiectasia
Type of study:
Observational study
/
Risk factors
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2002
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
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