Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
Genet. mol. biol
;
25(1): 21-34, 2002. tab
Article
in English
| LILACS
| ID: lil-324981
ABSTRACT
Seven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela
Full text:
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Index:
LILACS (Americas)
Main subject:
Haplotypes
/
Globins
/
Hemoglobin, Sickle
/
Anemia, Sickle Cell
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
South America
/
Venezuela
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2002
Type:
Article
Affiliation country:
Venezuela
Institution/Affiliation country:
Hospital Central de Maracay/VE
/
Universidad Pedagógica Experimental Libertador Maracay/VE
/
Universidad de Carabobo Núcleo Aragua/VE
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